Oxidized LDL is highly reactive and associated with cellular toxicity. It can accumulate in the arterial wall of blood vessels, especially the coronary arteries, and not only lead to the formation and growth of atherosclerotic plaques but also induce inflammation by activating macrophages. With its dual role in plaque formation and coronary artery inflammation, oxLDL is a key driver of atherosclerosis in coronary artery disease and crucial risk factor for acute coronary syndrome, including heart attacks.