Recombinant Antibodies to an Oxidized Low-Density Lipoprotein Epitope Induce Rapid Regression of Atherosclerosis in Apobec-1-/- /Low-Density Lipoprotein Receptor-/- Mice

Schiopu et al, 2007, Journal of the American College of Cardiology, Volume 50, Issue 24, December 2007

The present study tested the hypothesis that treatment with human recombinant immunoglobulin G1 (IgG1) antibodies against a specific oxidized low-density lipoprotein (oxLDL) epitope will induce regression of existing atherosclerotic lesions in LDL receptor-deficient mice expressing apolipoprotein B-100 (apoB-100) (Apobec-1^−/−/LDLR^−/−).